Astros vs. Phillies odds, line: 2022 World Series Game 4 picks, predictions from computer model on 20-13 roll

Citizens Bank Park hosts Game 4 of the 2022 World Series on Wednesday night. Game 3 took place on Tuesday in Philadelphia, with the Phillies toppling the Houston Astros by a 7-0 margin. That victory gave the Phillies a 2-1 advantage in the best-of-seven series. Philadelphia will send Aaron Nola to the mound in Game 4, with Houston leaning on Cristian Javier.

First pitch is at 8:03 p.m. ET in Philadelphia. Caesars Sportsbook lists Philadelphia as the -115 (risk $115 to win $100) favorite on the money line in the latest Astros vs. Phillies odds. Houston is -105 and the over/under for total runs is set at 7.5. Before locking in any Phillies vs. Astros picks, be sure to see the 2022 World Series predictions from SportsLine’s proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it entered the 2022 World Series on a 20-13 roll on top-rated MLB money-line picks, returning more than $400. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen huge returns.

Now, the model has dialed in on Astros vs. Phillies and just revealed its coveted World Series 2022 picks and predictions. You can visit SportsLine now to see the model’s MLB picks. Here are the MLB odds and World Series betting lines for Phillies vs. Astros:

• Astros vs. Phillies money line: Astros -105, Phillies -115
• Astros vs. Phillies over/under: 7.5 runs
• Astros vs. Phillies run line: Astros -1.5 (+158)
• HOU: The Astros are 93-51 with no rest between games in 2022
• PHI: The Phillies are 79-67 with no rest between games in 2022
• Astros vs. Phillies picks: See picks at SportsLine

Featured Game | Philadelphia Phillies vs. Houston Astros

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Why you should back the Astros

Houston has 15 doubles and 15 home runs in 10 games, illustrating the team’s offensive firepower. While the Astros were blanked in Game 3, Houston was a top-three team in myriad offensive categories this season, including runs scored, home runs, strikeout avoidance, OPS, total bases, and walks. 

On the run prevention side, the Astros are unquestionably top-tier, especially in the bullpen. Houston’s depth is unmatched, with the Astros leading MLB in ERA (2.80) and strikeout rate (10.45 per nine innings) from relief pitchers during the regular season. Houston also has a sparkling 0.81 ERA in 44.1 relief innings during the postseason, with relievers generating 56 strikeouts against 15 walks. At the top of the game, Cristian Javier takes the ball for the Astros, and he has a 1.35 ERA in the 2022 postseason with opponents producing a .494 OPS against him. Javier also posted a 2.54 ERA and 0.95 WHIP in 148.2 regular season innings.

Why you should back the Phillies

Philadelphia has a tremendous starting pitcher projected to take the ball in Game 4. Right-hander Aaron Nola led all MLB starting pitchers this season in wins above replacement, and he produced a 3.25 ERA in 205 innings of work. Nola had the best walk rate in the National League, issuing only 1.3 walks per nine innings, and he paired that with a tremendous 10.3 strikeouts per nine innings. Nola generated a 0.96 WHIP in 2022, and opponents had only a .604 OPS against him. 

On the offensive side, Philadelphia leans on power, including a .422 slugging percentage and a top-three mark in the National League in total bases in 2022. The Phillies were also in the top five of the league in runs scored, hits, home runs, batting average, OPS, and on-base percentage. Philadelphia also has the edge playing at home, with Bryce Harper leading an offense that is capable of putting up crooked numbers at any point.

How to make Phillies vs. Astros picks

SportsLine’s model is leaning Over on the total, projecting 7.9 combined runs. It also says one side of the money line has all the value. You can only get the model’s World Series Game 4 pick at SportsLine. 

So who wins Astros vs. Phillies World Series Game 4? And which side of the money line has all the value? Visit SportsLine now to see which side of the Phillies vs. Astros money line to jump on, all from the advanced model that is on a 20-13 roll on top-rated MLB money-line picks, and find out.