Several contenders have a chance to make a statement as the Week 4 college football schedule unfolds. No. 4 Michigan has faced one of the nation’s easiest schedules so far, but the Wolverines start Big Ten play against Maryland this week. The Week 4 college football odds from Caesars Sportsbook list the Wolverines at -17 in that one. No. 11 Tennessee has struggled against Florida in recent years, but the Vols are laying 10.5 points against the No. 20 Gators in the Week 4 college football spreads as those rivals meet up in the SEC on CBS game.
Other notable college football lines include No. 6 Oklahoma -13 against Kansas State, No. 5 Clemson -7 against Wake Forest, No. 3 Ohio State -17.5 against Kansas State and No. 10 Arkansas +2.5 against No. 23 Texas A&M. Which spreads, totals and money lines should you target in your college football bets this week? Before locking in any Week 4 college football picks for those games or others, be sure to see the latest college football predictions from SportsLine’s advanced computer model.
The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of more than $3,300 for $100 players on its top-rated college football picks against the spread. It enters Week 4 of the 2022 college football season on a 51-43 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.
Now, it has turned its attention to the latest Week 4 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.
Top college football predictions for Week 4
One of the college picks the model is high on in Week 4: No. 22 Texas (-5) goes on the road and covers against Texas Tech in a 3:30 p.m. ET matchup in Lubbock. The Longhorns have surpassed oddsmakers’ expectations in all three games this season, beating UTSA by 21 as 13-point favorites, covering +21 in a 20-19 loss to Alabama and knocking off UL Monroe 52-10 as 37.5-point favorites. Now they’re relatively small favorites against a Red Raiders squad they appear to have a talent edge over.
Bijan Robinson is perhaps the nation’s best running back, and SportsLine’s model projects that he’ll clear 100 yards on the ground with room to spare. Texas piles up 42 points in the simulations, helping the Longhorns cover in well over 60% of simulations. The Over 60, meanwhile, hits almost 70% of the time, making this a game to consider targeting in your college football parlays.Â
Another one of the model’s college football picks: No. 7 USC has no problem going on the road against covering -6.5 against Oregon State in a 9:30 p.m. ET start. Both teams played Fresno State in their last FBS matchup, so that can serve as a good baseline for this one. USC trounced the Bulldogs 45-17, while Oregon State survived in a 35-32 win.Â
Lincoln Riley’s impact on the USC program has been obvious through three week, and the Trojans have rolled to three wins and three covers. They’ve put up at least 40 points in each game, and SportsLine’s model projects almost 50 this week as USC covers nearly 70% of the time. See which other teams the model likes here.
How to make college football picks for Week 4
The model has also made the call on who wins and covers in every other FBS matchup in Week 4, and it says a Top 25 favorite will go down hard in one of the week’s biggest games. You can only get every pick for every game at SportsLine.
So what college football picks can you make with confidence? And which Top 25 favorite goes down hard? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned more than $3,300 in profit over the past six-plus seasons, and find out.
College football odds for Week 4 (via Caesars)
See full Week 4 college football picks, odds, predictions here
Thursday, Sept. 22
West Virginia at Virginia Tech (+3, 53)
Featured Game | Virginia Tech Hokies vs. West Virginia Mountaineers
Coastal Carolina at Georgia State (+2.5, 63.5)
Featured Game | Georgia State Panthers vs. Coastal Carolina Chanticleers
Friday, Sept. 23
Virginia at Syracuse (-9.5, 54.5)
Featured Game | Syracuse Orange vs. Virginia Cavaliers
Nevada at Air Force (-24.5, 48.5)
Featured Game | Air Force Falcons vs. Nevada Wolf Pack
Boise State at UTEP (+16, 46.5)
Featured Game | UTEP Miners vs. Boise State Broncos
Saturday, Sept. 24
Kent State at Georgia (-44, 59.5)
Maryland at Michigan (-17, 62.5)
Featured Game | Michigan Wolverines vs. Maryland Terrapins
Central Michigan at Penn State (-26, 60.5)
Featured Game | Penn State Nittany Lions vs. Central Michigan Chippewas
Clemson at Wake Forest (+7, 56.5)
Featured Game | Wake Forest Demon Deacons vs. Clemson Tigers
Baylor at Iowa State (-3, 44.5)
Featured Game | Iowa State Cyclones vs. Baylor Bears
Florida at Tennessee (-10.5, 63.5)
Featured Game | Tennessee Volunteers vs. Florida Gators
Texas at Texas Tech (+5, 60)
Featured Game | Texas Tech Red Raiders vs. Texas Longhorns
Tulsa at Ole Miss (-20, 63)
Featured Game | Ole Miss Rebels vs. Tulsa Golden Hurricane
Oregon at Washington State (+6, 53.5)
Featured Game | Washington State Cougars vs. Oregon Ducks
Northern Illinois at Kentucky (-25.5, 53)
Featured Game | Kentucky Wildcats vs. Northern Illinois Huskies
Arkansas at Texas A&M (-2.5, 48)
Featured Game | Texas A&M Aggies vs. Arkansas Razorbacks
Wisconsin at Ohio State (-18, 56.5)
Featured Game | Ohio State Buckeyes vs. Wisconsin Badgers
Vanderbilt at Alabama (-40.5, 59)
Kansas State at Oklahoma (-13, 53.5)
Featured Game | Oklahoma Sooners vs. Kansas State Wildcats
USC at Oregon State (+6.5, 68)
Featured Game | Oregon State Beavers vs. USC Trojans
Utah at Arizona State (+15, 52)
Featured Game | Arizona State Sun Devils vs. Utah Utes
Stanford at Washington (-12, 61)
Featured Game | Washington Huskies vs. Stanford Cardinal